Whether EMMPRIN is responsible for such effect is yet to be investigated, although more EMMPRIN containing EVs were released in response to Ivabradine, and EMMPRIN containing cardiac EVs inhibited cell death and induced cell migration and proliferation of H9c2 cardiac derived cell cultures, accordingly with EMMPRIN-induced MMP-activation as in EMMPRIN-containing EVs from cancer cells [12,13,14]. The gene discussed is BSG; the disease is cancer.