Neutrophilia provide a favorable tumor microenvironment for cancer progression by secreting many inflammation mediators such as tumor necrosis factor alpha (TNF-α), vascular endothelia growth factor (VEGF), interleukin-2 (IL-2), interleukin-6 (IL-6), and interleukin-10 (IL-10) [18]. The gene discussed is TNF; the disease is cancer.