These damaged ncRNAs are released into the microenvironment and stimulate the inflammatory response with the production of tumor necrosis factor α (TNF-α) and interleukin-6 (IL -6) in non-irradiated keratinocytes and peripheral blood mononuclear cells (PBMCs), increasing the extent of the damage and the development of cancer lesions [40]. This evidence concerns the gene TNF and cancer.