MALAT1 is elevated in CSCC and appears to play an oncogene role through the activation of the EGFR pathway [38], as already demonstrated in various tumor pathologies, such as lung cancer, laryngeal squamous cell carcinoma, ovarian cancer, bladder cancer, gastric cancer, and oral squamous cell carcinoma, in which it is associated with a poor response to cisplatin through various mechanisms such as the axis MALAT1/miR-101/SOX9, MALAT1/miR-101-3p/MCL1 and MALAT1/miR-101-3p/VEGF-C or the upregulation of multi-drug resistant proteins (MDR) and the PI3K7AKT pathway [122,123,124,125,126,127,128]. The gene discussed is MALAT1; the disease is gastric cancer.