Furthermore, children with obesity had greater number of macrophages infiltrated in AT compared to that of their lean peers (p < 0.001); however, macrophage number was not correlated with serum levels of high-sensitivity c-reactive protein (hs-CRP) nor IL-6 and TNF-α (serum levels and AT expression) [138]. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.