EFEMP1 and breast angiosarcoma: Although it remains unclear if such upregulation represents a causal, consequential, or collateral phenomenon in cholestatic disease, given that fibulin-3 is normally more highly expressed in both cholangiocytes and portal fibroblasts relative to other liver cell types [106], the question of whether fibulin-3 is implicated in the pathogenesis of BA may warrant further investigation.