Importantly, these are pathways with which fibulin-3 has been linked in other contexts, including cell differentiation (as a negative regulator of chondrocyte differentiation [91]); developmental processes (namely murine bone and cartilage development [50]); Notch signalling in cancer, as an activator of pro-invasive [92] and pro-angiogenic [93] Notch signalling in glioma; and vascular endothelial cell activity in angiogenesis [63]. This evidence concerns the gene EFEMP1 and central nervous system cancer.