EFEMP1 and open-angle glaucoma: Although GWASs have yet to associate EFEMP1 genetic variants directly with POAG [52,88], they have been linked to various endophenotypes which themselves are associated with glaucoma and have a certain degree of heritability, including intraocular pressure (IOP) [52,89,90], the elevation of which is a well-established risk factor for POAG; optic cup area(OCA) [54,88]; and vertical cup-disc ratio (VCDR) [88].