EFEMP1 and Inguinal hernia: The primary defect in Efemp1 KO mice is a deficiency of elastic fibres specifically within fascia tissue, causing a phenotype of multiple herniations, including lateral bulges reflecting direct inguinal hernias, anorectal bulges reflecting indirect inguinal hernias in males and pelvic organ prolapse in females, and thoracic bulges representing protrusion of the xiphisternum through the fascial tip of the linea alba.