BCR and chronic myelogenous leukemia, BCR-ABL1 positive: TKIs used in CML management, with the exception of asciminib (binds a myristoyl site of the BCR-ABL1 protein, “locking” BCR-ABL1 into an inactive conformation via a mechanism other than binding to the kinase ATP-binding site), target the ATP binding pocket in the Abl1 kinase.