Unexpectedly, we noticed an impact of the histological progression of disease on ALP and GGT activity and on albumin concentration, perhaps because ALP and GGT are membrane-bound extracellular enzymes and are more dependent on bile duct obstruction, whereas albumin synthesis takes place in different hepatocyte compartments starting in ribosomes, continuing in endoplasmic reticulum, and ending in Golgi apparatus. Here, ALB is linked to cholestasis.