These data should make myostatin blocking an interesting strategy to counteract muscle loss in various conditions and diseases, however, while neutralizing antibodies such as MYO-029, AMG 74, LY2495655, or soluble receptor decoys such as ACE-11 and ACE-031 have significant beneficial effects on muscle mass and strength, they also exhibit several side effects including urticaria, aseptic meningitis, diarrhea, confusion, fatigue, and unintentional muscle contractions [79]. This evidence concerns the gene ACE and aseptic meningitis.