Furthermore, especially some genes for which evidence for functional roles in hypoxia has been demonstrated repeatedly and in cancer cells (e.g. L1CAM, ANGPTL4, CA9, VEGFA, LDHA, P4HA1, LOX, LOXL2, LOXL4) are almost all significantly upregulated in both BRC12/CD184lo and BRC13/CD49flo cells (S3 Table). The gene discussed is CA9; the disease is cancer.