In this study, we found that the expression of LNK in human adipose tissue is positively correlated with serum glucose and insulin in the obese group, so we hypothesize that LNK was involved in glucolipid metabolism and may contribute to alterations in glucose homeostasis and lipid metabolism associated with obesity-induced insulin resistance. This evidence concerns the gene SH2B3 and obesity due to melanocortin 4 receptor deficiency.