For example, infusion of NMDA receptor CSF antibodies into mice, with clear binding to the hippocampi, did not produce any evidence of movement disorder, one of the key features of the human disease [40]; a single injection of NMDAR IgG [41] or infusion of LGI1 antibodies [42], both of which are associated with epilepsy, produced no spontaneous seizures although there was EEG or ex vivo evidence of neuronal hyperexcitability. This evidence concerns the gene LGI1 and epilepsy.