However previous meta-analysis found that PD-L1 expression was correlated with tumor stage [21] and gender [22] and tumor location [23], which results were unreliable due to high heterogeneity (all I2 > 70%) [21–23] and the incorrect analytical model (all selected the fixed effects model that is available for I2 < 50%) [21–23]. Here, CD274 is linked to neoplasm.