SOX11 is a unique transcription factor, since it does not appear to be expressed in normal mammary epithelial cells after birth in either mouse or human and therefore is well-poised to reactivate developmental pathways when expressed in breast cancers (Oliemuller et al., 2017; Tsang et al., 2020; Wansbury et al., 2011; Zvelebil et al., 2013). The gene discussed is SOX11; the disease is breast carcinoma.