In the model described here, SOX11 is expressed at higher levels in DCIS.com cells driven from the EF1A promoter after induction with doxycycline (DOX), when compared to another model we have previously used to study DCIS progression, in which low levels of SOX11 expression is constitutively driven by the CMV promoter (Oliemuller et al., 2017). The gene discussed is SOX11; the disease is ductal breast carcinoma in situ.