Tumours formed from iSOX11 DCIS cells grew out quickly when (1250 or 2000 ppm) DOX-chow was replaced with normal chow, suggesting that high levels of SOX11 could keep tumours in a non-proliferative state and that upon DOX withdrawal, proliferation resumed and the ostensible quiescent state is a reversible condition (Figure 2—figure supplement 3). Here, SOX11 is linked to ductal breast carcinoma in situ.