After xenografting iSOX11Br cells into the tail vein, mice that had been fed normal chow had a greater metastatic burden in the lungs compared to mice fed DOX-containing chow to induce SOX11 expression, similar to results observed using the parental iSOX11 DCIS cell line (Figure 5B–D). This evidence concerns the gene SOX11 and ductal breast carcinoma in situ.