GAS6 is a crucial factor involved in paracrine stroma‐tumor cell interaction, as evidenced by several studies (Tjwa et al, 2008), and the GAS6‐AXL axis has been implicated in the reciprocal signaling between PDAC and stromal cells induced by KRASG12D mutation (Tape et al, 2016). This evidence concerns the gene AXL and neoplasm.