Finally, further studies are needed to define the atRA role in CRBP-1+ H460 cell line and to clarify if those CRBP-1-related pathways involved in NSCLC carcinogenesis may be modulated, with a potential beneficial opportunity for a more personalized chemotherapeutic regimens employing adjuvant retinoid therapy. Here, RBP1 is linked to non-small cell lung carcinoma.