C11orf95-RELAfus1 was identified as the most frequently occurring fusion subtype in supratentorial ependymoma with C11orf95-RELA fusion (ST-EPN-RELA), containing almost the entire RELA gene except the first two codons fused to a truncated C11orf95 gene fragment (C11orf95fus1) harboring two and a half exons out of five exons of the full-size gene [14]. The gene discussed is MME; the disease is supratentorial ependymoma.