While the HEK293T transgenic cell models allow the dissection of the molecular function of C11orf95-RELA and its constituents, to obtain insights of the epigenomic and transcriptomic effects of C11orf95-RELA in the context of ependymoma, we performed further experiments in an ependymoma cell line, BXD-1425-EPN [19] that was established from an orthotopic patient-derived xenograft (PDX) originating from a ST-EPN-RELA tumor. This evidence concerns the gene MME and ependymoma.