RELA and ependymoma: Although the overexpression of C11orf95fus1 alone in HEK293T cells was not sufficient to drive ependymoma-like transcriptomic transformation, the ChIP-seq with both HEK293T and BXD-1425-EPN cells shows that the C11orf95 portion of the fusion plays a critical role binding to DNA and thus serving as a shuttle for the entry of RELA to the nucleus.