Based on our work, an unbalanced response to RF-stalling resulting in diminished cell proliferation during development (Klingseisen and Jackson 2011) provides a plausible explanation for causative DNA2 mutations in patients with the primordial dwarfism disorder Seckel syndrome (Shaheen et al. 2014; Tarnauskaitė et al. 2019). Here, DNA2 is linked to Seckel syndrome.