Both reactive astrocytes and endothelial cells within peri-radiation-induced angiogenic regions have been shown to abundantly express VEGF.12 As such, it is possible that radiation-induced inflammatory changes contributed to the growth of the patient’s hemangioblastoma via upregulation of the VEGF/VEGF receptor angiogenic signaling pathway within and surrounding the tumor itself. This evidence concerns the gene VEGFA and hemangioblastoma.