VEGFA and neoplasm: Moreover, in instances where hemangioblastomas are refractory to surgical and radiosurgical intervention, bevacizumab may have a multifaceted role, where it not only inhibits VEGF signaling intrinsic to the hemangioblastoma, but also dampens VEGF signaling induced by inflammatory changes that arise post-SRS which can contribute to further tumor progression and adverse radiation effects.