IGF1 and osteosarcoma: Figure 6(b) indicated that the protein levels of IL-10, TGF-β1, VEGFA, and IGF-1 were significantly increased in osteosarcoma tissues, which was consistent with the RT-PCR results. Collectively, these data indicated that CD163+EPOR+ TAMs expressed higher M2 cytokines and surface markers in osteosarcoma tissues.