Additionally, TAMs secrete anti-inflammatory cytokines (referred to as M2 cytokines herein) such as interleukin- (IL-) 10, transforming growth factor- (TGF-) β1, insulin growth factor- (IGF-) 1, and vascular endothelial growth factor A (VEGFA), which can promote cancer progression by different mechanisms [14–16]. The gene discussed is VEGFA; the disease is cancer.