Therefore, we concluded that BBR can effectively protect T2D rats against IR by regulating the expression of cAMP, PKA, PPM1B, PPARγ, LRP1, GLUT4, NF-κB p65, JNK, IKKβ, IRS-1, IRS-2, PI3K, and AKT in the liver. This evidence concerns the gene IRS2 and type 2 diabetes mellitus.