The purpose of the current research was to investigate preliminarily whether the molecular mechanism of BBR treats T2D by regulating the expression of PPM1B, PPARγ, LRP1, GLUT4, NF-κB p65, JNK, IKKβ, IRS-1, IRS-2, PI3K p85, and AKT in the ZDF rats' liver tissue and HepG2-IR cells. This evidence concerns the gene PPM1B and type 2 diabetes mellitus.