TNF and pancreatic insulinoma: In addition, to elucidate the molecular mechanisms of PRDX6 protective activity, rat insulinoma RIN-m5F сells were cultured with cytokines (TNF-α and IL-1β) and used as an in vitro diabetic model to measure the ROS secretion, β cell apoptosis, and the activity of the NF-κB and JNK signaling pathways.