PRIM1 and hepatocellular carcinoma: Moreover, subgroup analysis found that PRIM1 overexpression might be considered a risk factor for the 1-year (HR = 3.44 (1.88-6.27), log-rank p = 2e − 05), 3-year (HR = 2.48 (1.64-3.74), log-rank p = 7.5e − 06), and 5-year (HR = 1.89 (1.31-2.72), log-rank p = 5e − 04) OS in patients with HCC (Figures 3(c)–3(e)).