Furthermore, the investigation on the correlation between tumor-infiltrating immune cells (TIICs) and PRIM1 expression in HCC showed that PRIM1 expression was positively correlated with the number of B cells, neutrophils, macrophages, and dendritic cells, indicating that PRIM1 expression might be a potential biomarker for immunotherapy in HCC. Here, PRIM1 is linked to hepatocellular carcinoma.