Studies [51] have shown that ADAM0 can hydrolyze the receptors of the outer membrane of Notch protein, suggesting that in myocardial ischemia, ADAM10 may induce angiogenesis, inhibit cardiomyocyte apoptosis by activating the Notch signaling pathway, and play a role in improving myocardial ischemia. This evidence concerns the gene ADAM10 and myocardial ischemia.