So far, a previous study has demonstrated the interaction between ADH1B and/or ALDH2 risk alleles and environmental risk factor through SNP genotyping in ESCC [5], and another study has identified 26 significantly mutated genes in ESCC, where TENM3 mutations and the TP53 hotspot mutation p.R213∗ were stated to be related to poor prognosis [6]. Here, TENM3 is linked to esophageal squamous cell carcinoma.