Actually, only Song et al. [24] and Zhang et al. [18] reported the positive relation of PIK3CA mutation with OS (HR = 2.37; 95 CI: 1.17-4.83) and PFS (HR = 2.18; 95% CI: 1.05-4.53) separately, which meant most of the relevant studies manifested that PIK3CA mutation did not affect the survival of NSCLC patients significantly. The gene discussed is PIK3CA; the disease is non-small cell lung carcinoma.