It has been reported that in the rats septic model injected by LPS for 24 h, the expression of miR-146a increased, which inhibited the activation of toll-like receptor 4/nuclear factor kappa-B (TLR-4/NF-κB) signaling pathways and alleviated the cardiomyocytes apoptosis and injury caused by sepsis [21]. This evidence concerns the gene TLR4 and Sepsis.