In our study, we found that the Akt2 and p-Akt2 were activated in the LPS-treated rat models and H9C2 cardiomyocytes stimulated by LPS, indicating that Akt2 may be a functional molecule in the pathogenesis in the sepsis-induced myocardial depression, however, it still needs to be determined if Akt2 is a vital regulatory molecule in this context. This evidence concerns the gene AKT2 and Sepsis.