Of the 112 low-grade meningiomas, 48 (42.9%) exhibited a high HIF-1α expression, whereas of the 48 high-grade meningiomas, 30 (62.5%) exhibited a high HIF-1α expression, which was also statistically significant (P = 0.023) (Table 1). The gene discussed is HIF1A; the disease is meningioma.