HIF1A and neoplasm: Additionally, there was a significant difference in the expression of HIF-1α between tumor sizes of <4 cm, 4–6 cm, and >6 cm, with a proportion of 41.7% (43/103), 68.2% (30/44), and 38.5% (5/13), respectively (χ2 = 9.222, P = 0.010) (Table 1).