Different iNOS inhibitors were studied by Armengou et al., in which N-(3-(aminomethyl)benzyl) acetamidine (1400W) administrated at the onset of ischemia and at 8-hour intervals for 3 days after MCAO resulted in a 55% reduction of infarct size, as measured 72 hours after induction of cerebral ischemia [65]. This evidence concerns the gene NOS2 and Cerebral ischemia.