TAP-nanoemulsion triggered apoptosis of human malignant melanoma in the lung by inhibiting Bcl-2, cyclins D1 and E, NF-κB, ERK, MEK, and MMP-1 and MMP-9 and increasing cleaved caspase-9 and caspase-3, ATM, and p21. The gene discussed is CASP9; the disease is melanoma.