For example, hsa_circRNA_100873 upregulation was correlated to lymphatic metastasis of ESCC [13], and Circ-SLC7A5 was validated as a potential prognostic circulating biomarker for detection of ESCC, which was correlated to advanced stage and worse prognosis [14]. The gene discussed is SLC7A5; the disease is esophageal squamous cell carcinoma.