Notably, the platelet-derived growth factor receptor [22, 23], PDGFRA and PDGFRB, was significantly upregulated in the high-risk group, further demonstrating that the PDGF/PDGFR and PI3K-Akt signaling pathway were responsible for the worse prognostic outcome and might be the potential therapeutic targets in gastric cancer. Here, PDGFRB is linked to gastric cancer.