TGFB1 and Glomerular sclerosis: Along with 44 differential metabolites identified, SFR was found to exert potent effects of alleviating glomerular sclerosis and interstitial fibrosis in the kidney, mainly via integrated regulations on the metabolism of homocysteine, L-carnitine, and epinephrine, as well as the expression of TGFβ-1 (Figure 6).