A KEGG enrichment analysis of the candidate targets in this PPI network disclosed 10 ischemic stroke-related signaling pathways, namely, HIF-1, FoxO, adherens junction, NF-kappa B, PI3K-Akt, TGF-beta, NOD-like receptor, Hippo, apoptosis, and TNF (ordered in P value, Figure 4(b)). Here, TNF is linked to ischemic stroke.