In this present study, it was aimed at evaluating the association between seven important H. pylori virulence genes, vacA, cagA, oipA, hpaA, babA, napA, dupA, ureA, and ureB, with the clarithromycin and fluoroquinolone resistance in H. pylori-infected patients with gastritis. The gene discussed is S100A8; the disease is gastritis.