In contrast, Ki20227 treatment could decrease the NLRP3, NF-κB, and cleaved caspase 1 protein expression in stroke+Ki20227 group after building stroke model with PBS treatment (##P < 0.01, ###P < 0.001, ^^P < 0.01, ^^^P < 0.001) in Figures 5(b)–5(d). This evidence concerns the gene CASP1 and stroke disorder.