For instance, the APP gene family and its products are able to modulate phenomena of hippocampal long-term plasticity [34], as well as the microglial TREM2 gene might have a role in the synaptic loss depending on the AD stage [35], whereas the CHMP2 gene regulates synaptic plasticity in dendritic spines [36]. This evidence concerns the gene TREM2 and Alzheimer disease.