In the basis of current understanding, the IL-33/ST2 pathway primarily plays detrimental roles in various allergic disorders [55, 56] such as asthma and atopic dermatitis and in multiple autoimmune diseases [47, 57] such as rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, and inflammatory bowel diseases [58]. Here, IL1RL1 is linked to systemic sclerosis.