VEGFA and neoplasm: Interestingly, pre-treatment diffusion-weighted magnetic resonance imaging (DWI or DW-MRI) estimates of the apparent diffusion coefficient (ADC) within the enhancing lesion have been shown to be predictive for survival benefit on anti-VEGF treatment in the recurrent setting in both single-center16–18 and multicenter studies19–21 suggesting a potential mechanistic link between water mobility within the tumor and anti-VEGF treatment efficacy.