However, GM-CSF has also been shown to promote tumor progression, possibly via activation of Signal transducer and activator of transcription 3 (STAT3) or upregulation of vascular endothelial growth factor (VEGF)35, and decreasing GM-CSF levels has been shown to suppress glioblastoma cell growth indicating a potential stimulatory effect on glioblastoma progression39. This evidence concerns the gene STAT3 and neoplasm.