Flow cytometry analysis (sample flow gating strategy of 344SQ tumors shown in Supplementary Fig. 3) revealed that LOXL2 inhibition or knockdown increased tumor-infiltrating CD8+ T cells and decreased PD-1+TIM-3+ exhausted CD8+ T cells (Fig. 2d and e), comparable to 393P tumors with low baseline levels of collagen, with no significant effect on total CD3+ T cells (Supplementary Fig. 4a). This evidence concerns the gene LOXL2 and neoplasm.