CD8A and metastatic neoplasm: Histologic analyses of primary and metastatic lung tumor tissues showed an increase in CD8 T cell infiltration with no reduction in collagen deposition when LAIR2 was constitutively expressed, while the addition of PD-1 blockade further increased CD8 T cell infiltration in primary and metastatic tumors with no effect on collagen deposition (Fig. 5d and e, Supplementary Fig. 10c).