Co-culture experiments demonstrated that SHP-1 inhibition, but not SHP-2, reduced tumor cell numbers only in the presence of splenocytes in 393P (TPI-1 IC50 = 72.24 μM; SHP099 IC50 = 94.13 μM; Spleens + TPI-1 IC50 = 20.37 μM; Spleens + SHP099 IC50 = 60.47 μM, Fig. 6f) and 344SQ cells (TPI-1 IC50 = 86.72 μM; SHP099 IC50 = 101.2 μM; Spleens + TPI-1 IC50 = 22.22 μM; Spleens + SHP099 IC50 = 59.15 μM, Fig. 6f). This evidence concerns the gene NR0B2 and neoplasm.