In this study, we provide gene regulation data on AR signalling in human macrophages and show that activation of AR signalling in macrophages increases migration and invasion of PCa-derived cancer cells, mediated by upregulation of the Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) receptor and its downstream cytokines and promotion of TAM differentiation. This evidence concerns the gene TREM1 and posterior cortical atrophy.