ONECUT2 and cancer: Notably, our data show that the expression patterns of Onecut1 and Onecut2 were opposite: Onecut1 was expressed only in ductal cells (Supplementary Fig. 5o) but not in metaplastic or tumor cells, while Onecut2 was expressed in metaplastic cells, mouse and human cancer cells (Fig. 2, Supplementary Fig. 4k–m) and is, therefore, more relevant to the development of PDAC that originates from acinar cells.