Among all lipid trait SNPs, 30% have pleiotropic effects on BMI, T2D, or SBP at a Bonferroni-corrected significance threshold of P < 2 × 10−5, including 20% of LDL-C SNPs, 31% of HDL-C SNPs, and 37% of TG SNPs (Table 1; Fig. 1). Here, COG2 is linked to type 2 diabetes mellitus.