FADS1 and coronary artery disorder: We next performed monogenic univariable MR of TGs in CAD at LPL, ANGTPL4, MLXIPL, and FADS1. Nine distinct SNPs in LPL encoding LPL, which hydrolyzes TGs in all lipoprotein classes (55), are associated with large and heterogeneous, but consistently deleterious, effects on CAD per unit increase in TGs.