In order to interrogate the basis of heterogeneity of HDL-C and TG associations with CAD, we also selected mechanistically well-defined loci carrying SNPs with moderate lipid trait effects and CAD effects that are inconsistent with the CAD effects of large effect SNPs, which occurred at LCAT and LIPC for HDL-C, and MLXIPL and FADS1 for TG. The gene discussed is LCAT; the disease is coronary artery disorder.