We focused on HDL-C and TGs for this analysis because the causal effect of LDL-C in CAD is well-established and the effects of LDL-C SNPs on CAD are relatively homogeneous (Fig. 2A); monogenic univariable MR of mechanistically well-defined LDL-C SNPs of large lipid trait effect size, e.g., PCSK9 and LDLR (Supplemental Table S5), has been previously reported (41). This evidence concerns the gene COG2 and coronary artery disorder.