We performed monogenic univariable MR of HDL-C in CAD at LIPG, LCAT, and LIPC. The LIPG locus encodes endothelial lipase, which modifies HDL-C by catabolizing HDL phospholipids; this activity decreases HDL stability and may cause the resulting phospholipid-poor HDL to be a poorer cholesterol acceptor (46, 47, 48). Here, LCAT is linked to coronary artery disorder.