CETP and coronary artery disorder: Our conclusion that HDL-C and TGs are associated with locus- and mechanism-specific causal effects on CAD is not in disagreement with the negative results of some randomized controlled trials of HDL-C-raising and TG-lowering therapies, including fibrates, niacin, and cholesteryl ester transfer protein inhibitors (76, 77, 78, 79), as the reported MR associations represent a composite of hundreds of distinct lipid-modifying mechanisms (17).