CD274 and non-small cell lung carcinoma: In comparison, ORRs in studies of avelumab in patients with platinum-treated advanced NSCLC, who were unselected for PD-L1 status, were 14% in a separate phase I cohort of the JAVELIN Solid Tumor trial22 and 15% in the phase III JAVELIN Lung 200 trial.23 In the current study, patients with ≥50% and ≥80% PD-L1-positive tumors had ORRs (by RECIST 1.1) of 22.6% and 26.3%, respectively.