Cited1Cre;Fgf8f/Δ;Fgf17Δ/Δ;Fgf18f/Δ embryos displayed a 33% rate of omphalocele (Fig. 6J, Fig. S8J), which was significantly lower than the 71% observed in TCre;Fgf8f/Δ;Fgf17Δ/Δ;Fgf18f/Δ embryos (P=0.0139, two-tailed Fisher's exact test) because in the Cited1Cre;Fgf8f/Δ;Fgf17Δ/Δ;Fgf18f/Δ embryos the PSM domain of Fgf8 remained intact (Fig. 6F). The gene discussed is FGF8; the disease is omphalocele.