It was observed that HCQ was associated with delayed SLE onset in CTD [34], decrease the risk of disease flare in pregnant SLE patients [35–37], increase the live birth rate, reduce preterm delivery in antiphospholipid antibodies (aPL) positive patients [38], and prevent congenital heart block in neonates exposed to anti-SSA and anti-SSB antibodies [39]. The gene discussed is SSB; the disease is systemic lupus erythematosus.