A recent meta-analysis of > 2900 patients T2D treated with biologics that block IL-1 signalling (anakinra, canakinumab, gevokizumab, LY2189102) demonstrated a significant overall reduction in HbA1c of 0.32%; this included a study of patients with RA and T2D that showed a reduction of > 0.8% [21]. Here, IL1B is linked to type 2 diabetes mellitus.