To differentially express Prdx6 we crossed APPSWE/PS1dE9 (APP/Prdx6+/+) AD Tg model mice [12, 13] with mice transgenically over-expressing Prdx6129X1/SvJallele on the wild-type Prdx6 background (Prdx6+/+/Tg1/1) [15] or with Prdx6 knock out (Prdx6−/−) mice [18]. The gene discussed is PRDX6; the disease is Alzheimer disease.