TREM2 and Alzheimer disease: Diminished number of periplaque microglial cells and microglia phagocytosis markers remain consistent with this more diffuse plaque morphology, resembling plaques in AD mice with Trem2 hemizygocity or those harboring Trem2 R47H mutant, both of which confer loss of TREM2 function and impair Aβ proteostatic function of microglia [29].