The results of the pooled analysis revealed that HOXD10 was not conducive to the distant metastasis of GC (HOXD10: OR = 0.34, 95% CI: 0.19–0.60), but that HOXC10 and HOXA11 promoted distant metastasis of GC (HOXC10: OR = 5.55, 95% CI: 1.42–21.61 and HOXA11: OR = 19.02, 95% CI: 1.07–337.91) (Fig. 6b). This evidence concerns the gene HOXD10 and gastric cancer.