In the pooled analysis of the effects of HOX proteins on the GC prognosis, HOXB9, HOXD10 and HOXA5 were correlated with a good prognosis in patients with GC, while HOXA13, HOXC6, HOXB7, HOXA1, HOXC9, HOXC10, HOXD4, HOXA1 and HOXD9 were related to a poor prognosis. The gene discussed is HOXD4; the disease is gastric cancer.