This is in agreement with a recent finding that NR4A1 regulates B-cell survival in a T cell–independent response but not in a T cell–dependent response.23 In our models, we could not study the potential contribution of NR4A1 in B1 cells because these cells do not reconstitute well after irradiation, and, therefore, further experiments are needed to elucidate the role of NR4A1 in B1 cells during atherosclerosis. Here, NR4A1 is linked to atherosclerosis.