After 8 weeks on a high-fat/high-cholesterol diet, deletion of Nr4a1 specifically in MZB cells led to increased development of atherosclerosis in the aortic sinus (Figure 2A) and increased lipid deposition in the aortic arches (Figure V in the Data Supplement), without altering serum levels of total cholesterol, HDL-C, or triglycerides, compared with mice with WT MZB cells (Figure 2B through 2D). The gene discussed is NR4A1; the disease is atherosclerosis.